Could not load file or assembly App_Web…

This morning I had a nice bug to track down, for some reason the intranet web application
was failing for users in a certain role. I've got an exception handling block which
is shared amongst all new internal applications (webapps and winforms) which
allows exceptions to be logged to a server (via .NET Remoting rather than webservices)
so getting access to the bugger is easy, unless of course the service can't be reached
and in such case exceptions are logged in the Event Log and unless someone notifies
me of a problem I have no way of knowing (I could cache the exceptions locally and
retry at a later time when the service is backup but I never implemented it).

Could not load file or assembly 'App_Web_afcjvzm7, Version=0.0.0.0, Culture=neutral,
PublicKeyToken=null' or one of its dependencies. The system cannot find the file specified.

A quick google search uncovered a thread on
aspnet with a fair number of people suffering the same problem, it appears there is
a hotfix available which
is claimed to fix the problem, but noone has verified it does. The only solution in
the short term seems to be to make a modification to the file thats causing the problem,
which isn't very practicable in the long run.